Comment on "The [4Fe4S] cluster of human DNA primase functions as a redox switch using DNA charge transport".
editorial · Level V
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- Record sourced from PubMed, PMID 28729486.
- Also identified by DOI 10.1126/science.aan2954.
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Abstract
O'Brien <i>et al</i> (Research Article, 24 February 2017, eaag1789) report that the iron-sulfur cluster of primase has a redox role in enzyme activity. Their analysis is based on a partially misfolded structure of the iron-sulfur cluster domain of primase. In the correctly folded structure, two of the three tyrosines putatively involved in electron transfer, Y345 and Y347, contact the RNA/DNA helix, providing an alternative explanation for the data of O'Brien <i>et al</i>.
Medical subject headings
- DNA Primase
- Iron-Sulfur Proteins