The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 28768171.
- Also identified by DOI 10.1016/j.cmet.2017.07.001 and PMC identifier 5560103.
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Abstract
The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth that responds to a diverse set of environmental inputs, including amino acids. Over the past 10 years, a number of proteins have been identified that help transmit amino acid availability to mTORC1. However, amino acid sensors for this pathway have only recently been discovered. Here, we review these recent advances and highlight the variety of unexplored questions that emerge from the identification of these sensors.
Medical subject headings
- Amino Acids
- Mechanistic Target of Rapamycin Complex 1