Off-Target <sup>18</sup>F-AV-1451 Binding in the Basal Ganglia Correlates with Age-Related Iron Accumulation.
cross_sectional · Level IV
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- Record sourced from PubMed, PMID 28775201.
- Also identified by DOI 10.2967/jnumed.117.195248.
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Abstract
Off-target binding in the basal ganglia is commonly observed in the <sup>18</sup>F-AV-1451 PET studies of the elderly. We sought to investigate the relationship between this phenomenon in the basal ganglia and iron accumulation using iron-sensitive R<sub>2</sub>* MRI. <b>Methods:</b> Fifty-nine healthy controls and 61 patients with Alzheimer disease and mild cognitive impairment underwent <sup>18</sup>F-AV-1451 PET and R<sub>2</sub>* MRI studies. A correlation analysis was performed for age, <sup>18</sup>F-AV-1451 binding, and R<sub>2</sub>* values. <b>Results:</b> There was an age-related increase in both <sup>18</sup>F-AV-1451 binding in the basal ganglia and R<sub>2</sub>* values in the putamen in both the controls and the Alzheimer disease/mild cognitive impairment patients. <sup>18</sup>F-AV-1451 binding in the basal ganglia increased with R<sub>2</sub>* values. <b>Conclusion:</b> Off-target <sup>18</sup>F-AV-1451 binding in the basal ganglia is associated with the age-related increases in iron accumulation. Postmortem studies are required to further investigate the nature of this association.
Medical subject headings
- Aging
- Basal Ganglia
- Carbolines
- Iron