Neutrophil extracellular trap (NET) levels in human plasma are associated with active TB.
Where this comes from
- Record sourced from PubMed, PMID 28777804.
- Also identified by DOI 10.1371/journal.pone.0182587 and PMC identifier 5544211.
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Abstract
Neutrophils are increasingly associated with tuberculosis (TB) disease. Neutrophil extracellular traps (NETs), which are released by neutrophils as a host antimicrobial defense mechanism, are also associated with tissue damage. However, a link between NET levels and TB disease has not been studied. Here we investigate plasma NETs levels in patients with active pulmonary tuberculosis using an ELISA assay that is suitable for high-throughput processing. We show that plasma NETs levels at baseline correlated with disease severity and decreased with antibiotic therapy. Our study demonstrates the biologic plausibility of measuring NETs in plasma samples from patients with TB.
Medical subject headings
- Biomarkers
- Extracellular Traps
- Mycobacterium
- Mycobacterium Infections, Nontuberculous
- Neutrophils
- Tuberculosis, Pulmonary