Blocking Bcl-2 resolves IL-13-mediated mucous cell hyperplasia in a Bik-dependent manner.
Level V
Where this comes from
- Record sourced from PubMed, PMID 28784260.
- Also identified by DOI 10.1016/j.jaci.2017.05.038 and PMC identifier 5675799.
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Abstract
Because IL-13 induces expression of the anti-apoptotic Bcl-2 and the pro-apoptotic Bik, blocking Bcl-2 causes a Bik-dependent death of hyperplastic mucous cells. Therefore, the Bcl-2-inhibitor, ABT-263, may be highly efficient in reducing mucous hypersecretion.
Medical subject headings
- Adaptor Proteins, Signal Transducing
- Epithelial Cells
- Interleukin-13
- Mitochondrial Proteins
- Proto-Oncogene Proteins c-bcl-2