Hereditary Colorectal Polyposis and Cancer Syndromes: A Primer on Diagnosis and Management.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 28786406.
- Also identified by DOI 10.1038/ajg.2017.212.
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Abstract
Colorectal cancer (CRC) is the fourth most common cancer amongst men and women. Between 3 and 6% of all CRCs are attributed to well-defined inherited syndromes, including Lynch syndrome, familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), and several hamartomatous polyposis conditions. Identification of these patients through family history and appropriate genetic testing can provide estimates of cancer risk that inform appropriate cancer screening, surveillance and/or preventative interventions. This narrative review examines the hereditary colorectal cancer and polyposis syndromes, their genetic basis, clinical management, and evidence supporting cancer screening.
Medical subject headings
- Adenomatous Polyposis Coli
- Colorectal Neoplasms, Hereditary Nonpolyposis
- Disease Management
- Early Detection of Cancer