Microparticle Release During Normal Cesarean Delivery.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 28787343.
- Also identified by DOI 10.1213/ANE.0000000000002290.
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Abstract
Coagulation increases during pregnancy and peaks during parturition. We hypothesized that an increase in microparticle (MP) levels in plasma occurs around the time of placental separation and subsides over several hours. We performed a prospective observational pilot study to investigate plasma MP levels in healthy parturients immediately before and after cesarean delivery. The primary outcome was MP levels at postdelivery time points compared to baseline levels. Samples underwent flow cytometry and staining to determine MP levels. Placental-derived MPs were further characterized for the presence of procoagulant proteins. Placental-derived MPs increased immediately after delivery before returning to baseline in healthy parturients.
Medical subject headings
- Cell-Derived Microparticles
- Cesarean Section