Challenges in the Design and Interpretation of Noninferiority Trials: Insights From Recent Stent Trials.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 28797360.
- Also identified by DOI 10.1016/j.jacc.2017.06.039.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The noninferiority design is used extensively in current clinical research, but its complex features may hamper the appropriate interpretation of such trials. Thus, understanding the pillars of noninferiority design is indispensable. The authors discuss fundamental concepts regarding the design and interpretation of noninferiority trials and then explore some common methodological criticism by analyzing a sample of contemporary coronary stent trials. Finally, the authors give an overall perspective to enhance the design and conduct of future trials.
Medical subject headings
- Cardiology
- Clinical Trials as Topic
- Coronary Artery Disease
- Myocardial Revascularization
- Stents