Transcription-Replication Conflicts: Orientation Matters.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 28802036.
- Also identified by DOI 10.1016/j.cell.2017.07.040.
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Abstract
Interference between DNA replication and transcription represents a major source of genomic instability. In this issue of Cell, Lang et al. and Hamperl et al. show that head-on collisions, but not codirectional collisions, impede fork progression in bacteria and in human cells by promoting the formation of RNA-DNA hybrids known as R-loops.
Medical subject headings
- DNA Replication
- Transcription, Genetic