Chromatin-Associated Protein SIN3B Prevents Prostate Cancer Progression by Inducing Senescence.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28807943.
- Also identified by DOI 10.1158/0008-5472.CAN-16-3410 and PMC identifier 5626631.
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Abstract
Distinguishing between indolent and aggressive prostate adenocarcinoma remains a priority to accurately identify patients who need therapeutic intervention. SIN3B has been implicated in the initiation of senescence <i>in vitro</i> Here we show that in a mouse model of prostate cancer, SIN3B provides a barrier to malignant progression. SIN3B was required for PTEN-induced cellular senescence and prevented progression to invasive prostate adenocarcinoma. Furthermore, SIN3B was downregulated in human prostate adenocarcinoma correlating with upregulation of its target genes. Our results suggest a tumor suppressor function for SIN3B that limits prostate adenocarcinoma progression, with potential implications for the use of SIN3B and its target genes as candidate diagnostic markers to distinguish indolent from aggressive disease. <i>Cancer Res; 77(19); 5339-48. ©2017 AACR</i>.
Medical subject headings
- Adenocarcinoma
- Cellular Senescence
- Disease Models, Animal
- PTEN Phosphohydrolase
- Prostatic Neoplasms
- Repressor Proteins