T1-/T2-weighted ratio differs in demyelinated cortex in multiple sclerosis.
basic_science · Level V
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- Record sourced from PubMed, PMID 28833377.
- Also identified by DOI 10.1002/ana.25019.
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Abstract
Detecting cortical demyelination in patients with multiple sclerosis (MS) is difficult. Using magnetic resonance imaging (MRI), ratio maps of T1-weighted (T1w) and T2-weighted (T2w) images may be sensitive to cortical myelin levels. In this MRI-histological study, postmortem in situ scans were acquired from 6 cadavers with MS on a 3T MRI machine. Immunocytochemistry was used to correlate myelin status and cortical T1w/T2w measures. The results showed that the T1w/T2w values significantly differed between demyelinated and myelinated cortex (p < 0.001). The T1w/T2w ratio maps may be a relatively simple, clinically feasible method to assess cortical demyelination. Ann Neurol 2017;82:635-639.
Medical subject headings
- Cerebral Cortex
- Magnetic Resonance Imaging
- Multiple Sclerosis
- Myelin Sheath