Cardiac Regeneration in the Human Left Ventricle After CorMatrix Implantation.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 28838516.
- Also identified by DOI 10.1016/j.athoracsur.2017.03.044.
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Abstract
CorMatrix is an organic extracellular matrix (ECM) derived from porcine small intestine submucosa and is used for pericardial closure and cardiac tissue repair. During explantation of a HeartMate II (Thoratec Corp, Pleasanton, CA) left ventricular assist device (LVAD) because of infection, CorMatrix was used to repair the left ventricular apex and aorta. Three months later, a HeartWare HVAD (HeartWare International, Inc, Framingham, MA) was implanted for recurrent heart failure. Excised apical CorMatrix samples showed cardiac tissue remodeling with viable cardiomyoblasts similar to native myocardium. Excised CorMatrix from the aorta showed organization of collagen and elastin similar to native aortic tissue.
Medical subject headings
- Aortic Diseases
- Blood Vessel Prosthesis Implantation
- Heart Failure
- Heart-Assist Devices