The Tropism of Pleiotrophin: Orchestrating Glioma Brain Invasion.
editorial · Level V
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- Record sourced from PubMed, PMID 28841413.
- Also identified by DOI 10.1016/j.cell.2017.08.011.
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Abstract
The lateral ventricle (LV) is a preferential location for brain tumor spread; however, the instructive cues responsible for this unique tropism were previously unknown. In this issue, Qin et al. elucidate the underlying mechanism, demonstrating that LV-neural progenitors secrete a pleiotrophin (PTN)-containing complex, which attracts glioma cells through ROCK/Rho activation.
Medical subject headings
- Carrier Proteins
- Glioma