Reprogramming Enhancers to Drive Metastasis.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 28841414.
- Also identified by DOI 10.1016/j.cell.2017.08.010.
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Abstract
Acquired molecular changes can promote the spreading of primary tumor cells to distant tissues. In this issue of Cell, Roe et al. show that metastatic progression of pancreatic cancer involves large-scale enhancer reprogramming by Foxa1, which activates transcriptional program specifying early endodermal stem cells.
Medical subject headings
- Enhancer Elements, Genetic
- Hepatocyte Nuclear Factor 3-alpha