Molecular epidemiology of <i>Pseudomonas aeruginosa</i> in an unsegregated bronchiectasis cohort sharing hospital facilities with a cystic fibrosis cohort.

Mitchelmore, Philip J; Randall, Joanna; Bull, Matthew J; Moore, Karen A; O'Neill, Paul A; Paszkiewicz, Konrad; Mahenthiralingam, Eshwar; Scotton, Chris J et al. · Thorax · 2017

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Abstract

While <i>Pseudomonas aeruginosa</i> (PA) cross-infection is well documented among patients with cystic fibrosis (CF), the equivalent risk among patients with non-CF bronchiectasis (NCFB) is unclear, particularly those managed alongside patients with CF. We performed analysis of PA within a single centre that manages an unsegregated NCFB cohort alongside a segregated CF cohort. We found no evidence of cross-infection between the two cohorts or within the segregated CF cohort. However, within the unsegregated NCFB cohort, evidence of cross-infection was found between three (of 46) patients. While we do not presently advocate any change in the management of our NCFB cohort, longitudinal surveillance is clearly warranted.