Association between mitochondrial DNA variations and schizophrenia in the northern Chinese Han population.
prospective_cohort · Level II
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- Record sourced from PubMed, PMID 28846698.
- Also identified by DOI 10.1371/journal.pone.0182769 and PMC identifier 5573569.
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Abstract
To determine whether mitochondrial DNA (mtDNA) variations are associated with schizophrenia, 313 patients with schizophrenia and 326 unaffected participants of the northern Chinese Han population were included in a prospective study. Single-nucleotide polymorphisms (SNPs) including C5178A, A10398G, G13708A, and C13928G were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Hypervariable regions I and II (HVSI and HVSII) were analyzed by sequencing. The results showed that the 4 SNPs and 11 haplotypes, composed of the 4 SNPs, did not differ significantly between patient and control groups. No significant association between haplogroups and the risk of schizophrenia was ascertained after Bonferroni correction. Drawing a conclusion, there was no evidence of an association between mtDNA (the 4 SNPs and the control region) and schizophrenia in the northern Chinese Han population.
Medical subject headings
- DNA, Mitochondrial
- Genetic Predisposition to Disease
- Polymorphism, Single Nucleotide
- Schizophrenia