Nitazoxanide is active against Mycobacterium leprae.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28850614.
- Also identified by DOI 10.1371/journal.pone.0184107 and PMC identifier 5574600.
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Abstract
Nitazoxanide (NTZ) is an anti-parasitic drug that also has activity against bacteria, including Mycobacterium tuberculosis. Our data using both radiorespirometry and live-dead staining in vitro demonstrate that NTZ similarly has bactericidal against M. leprae. Further, gavage of M. leprae-infected mice with NTZ at 25mg/kg provided anti-mycobacterial activity equivalent to rifampicin (RIF) at 10 mg/kg. This suggests that NTZ could be considered for leprosy treatment.
Medical subject headings
- Anti-Bacterial Agents
- Leprosy
- Mycobacterium leprae
- Thiazoles