Polyglutamine spinocerebellar ataxias - from genes to potential treatments.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 28855740.
- Also identified by DOI 10.1038/nrn.2017.92 and PMC identifier 6420820.
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Abstract
The dominantly inherited spinocerebellar ataxias (SCAs) are a large and diverse group of neurodegenerative diseases. The most prevalent SCAs (SCA1, SCA2, SCA3, SCA6 and SCA7) are caused by expansion of a glutamine-encoding CAG repeat in the affected gene. These SCAs represent a substantial portion of the polyglutamine neurodegenerative disorders and provide insight into this class of diseases as a whole. Recent years have seen considerable progress in deciphering the clinical, pathological, physiological and molecular aspects of the polyglutamine SCAs, with these advances establishing a solid base from which to pursue potential therapeutic approaches.
Medical subject headings
- Peptides
- Spinocerebellar Ataxias