The Myofilament Field Revisited in the Age of Cellular and Molecular Biology.
expert_opinion · Level V
Where this comes from
- Record sourced from PubMed, PMID 28860317.
- Also identified by DOI 10.1161/CIRCRESAHA.117.311629 and PMC identifier 5658034.
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Abstract
In the not too distant past, myofilament research attracted considerable attention after the discovery that mutations in myofilament genes cause cardiomyopathies. However, basic research has not been completely translated into therapies. This viewpoint discusses the need to develop innovative and integrative technologies and generate translatable models to uncover the complex biology of myofilament proteins to advance the field.
Medical subject headings
- Cell Biology
- Molecular Biology
- Myocardium
- Myofibrils