Therapeutic Radiometals Beyond <sup>177</sup>Lu and <sup>90</sup>Y: Production and Application of Promising α-Particle, β<sup>-</sup>-Particle, and Auger Electron Emitters.
review · Level V
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- Record sourced from PubMed, PMID 28864619.
- Also identified by DOI 10.2967/jnumed.116.186825.
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Abstract
In recent years, new α-particle-, β<sup>-</sup>-particle-, and Auger electron-emitting radiometals-such as <sup>67</sup>Cu, <sup>47</sup>Sc, <sup>166</sup>Ho, <sup>161</sup>Tb, <sup>149</sup>Tb, <sup>212</sup>Pb/<sup>212</sup>Bi, <sup>225</sup>Ac, and <sup>213</sup>Bi-have been produced and evaluated (pre)clinically for therapeutic purposes. In this short review article, the most important routes of production of these radiometals are critically discussed, as are examples of their application in preclinical and clinical studies.
Medical subject headings
- Alpha Particles
- Beta Particles
- Electrons
- Metals
- Radiochemistry
- Radioisotopes