Estimation of Pulse Transit Time From Radial Pressure Waveform Alone by Artificial Neural Network.

Abstract

To validate the feasibility of the estimation of pulse transit time (PTT) by artificial neural network (ANN) from radial pressure waveform alone. A cascade ANN with ten-fold cross validation was applied to invasively and simultaneously recorded aortic and radial pressure waveforms during rest and nitroglycerin infusion () for the estimation of mean and beat-to-beat PTT. The results of the ANN models were compared to a multiple linear regression (LR) model when the features of radial arterial pressure waveform in time and frequency domains were used as the predictors of the models. For the estimation of mean PTT and beat-to-beat PTT by ANN ( ), the correlation coefficient between the and the measured PTT () (mean: ; beat-to-beat: ) is higher than that between the PTT estimated by LR ( ) and (mean: ; beat-to-beat: ). The standard deviation (SD) of the difference between the and ( ; beat-to-beat: ) is significantly less than that between the and (; beat-to-beat: 10 ms), but no significant difference exists between their mean ( ). The lack of frequency features of radial pressure waveform caused obvious reduction in the correlation coefficient and SD of the difference between the and . The performance of the ANN was improved by increasing the sample number but not by increasing the neuron number. ANN is a potential method of PTT estimation from a single pressure measurement at radial artery.