The TREX1 Dinosaur Bites the Brain through the LINE.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 28886359.
- Also identified by DOI 10.1016/j.stem.2017.08.010.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
In this issue of Cell Stem Cell, Thomas et al. (2017) define the nature of accumulated ssDNA present in the neuron and astrocyte cytoplasm of TREX1 mutated stem cell-derived organoids. Accumulated ssDNAs are derived from LINE-1 endogenous retroelements, providing new clues as to the development of Aicardi-Goutières syndrome in the neural system.
Medical subject headings
- Autoimmune Diseases
- Autoimmune Diseases of the Nervous System
- Dinosaurs