Survival of the Fittest: Darwinian Selection Underpins Chemotherapy Resistance in AML.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 28886361.
- Also identified by DOI 10.1016/j.stem.2017.08.004.
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Abstract
Intratumor heterogeneity driving therapeutic resistance is a major challenge in cancer management. Recently in Nature, Shlush et al. (2017) provide a tour de force of genomics coupled to functional assays to demonstrate that resistance emerges from a pre-existing subpopulation of acute myeloid leukemia (AML) cells with a stem cell transcription program.
Medical subject headings
- Leukemia, Myeloid, Acute