CRISPR: Established Editor of Human Embryos?
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 28886363.
- Also identified by DOI 10.1016/j.stem.2017.08.007 and PMC identifier 5819596.
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Abstract
Off-target effects and mosaicism are major concerns for applying CRISPR-Cas9 to correct genetic mutations. A recent article in Nature by Ma et al. (2017) uses an elegant CRISPR-Cas9 approach that repairs a genetic mutation in human embryos with negligible mosaicism and no off-target effects, bringing this editing tool closer to clinical application.
Medical subject headings
- Clustered Regularly Interspaced Short Palindromic Repeats
- Gene Editing