The effect of fennel essential oil in combination with antibiotics on Staphylococcus aureus strains isolated from carriers.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28917968.
- Also identified by DOI 10.1016/j.burns.2017.04.014.
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Abstract
An increase in the number of staphylococcal infections and carriers among medical staff has forced us to seek more and more effective antibacterial agents. Bacteria from the Staphylococcus genus possessing different mechanisms of resistance are the cause of nosocomial infections. The objective of our investigations was susceptibility of S. aureus strains isolated from nasal vestibule of medical students to fennel essential oil. The GC-MS analysis of fennel essential oil revealed eleven constituents among which a majority of trans-anethole (80%) was found. The D-tests showed iMLS<sub>B</sub> (80%), cMLS<sub>B</sub> and MS<sub>B</sub> (10%) resistant phenotypes of S. aureus. The S. aureus isolates were intermediate to mupirocin (45%). Fennel essential oil increased the inhibition zone around cefoxitin, mupirocin, co-trimoxazole and ciprofloxacin with statistical significance. Our research showed that the fennel essential oil in combination with mupirocin may be considered as a natural alternative in eradication of S. aureus with iMLS<sub>B</sub>, cMLS<sub>B</sub>, MS<sub>B</sub> resistant phenotypes and is able to decrease the growth rate of antibiotic resistance.
Medical subject headings
- Anti-Bacterial Agents
- Foeniculum
- Oils, Volatile
- Staphylococcus aureus