Prion-like Domains Program Ewing's Sarcoma.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28938120.
- Also identified by DOI 10.1016/j.cell.2017.09.010 and PMC identifier 5639709.
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Abstract
Prion-like domains have emerged as important drivers of neurodegenerative disease. Now, Boulay et al. establish that the translocated prion-like domain of the oncogenic EWS-FLI1 fusion protein enables phase-separation events, which inappropriately recruit chromatin-remodeling factors to elicit the aberrant transcriptional programs underlying Ewing's sarcoma.
Medical subject headings
- RNA-Binding Protein EWS
- Sarcoma, Ewing