Huntingtin Fibrils Poke Membranes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28938121.
- Also identified by DOI 10.1016/j.cell.2017.09.009.
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Abstract
A hallmark of Huntington's disease is the presence of intracellular aggregates of mutant huntingtin, the pathological significance of which has long been debated. Using cryo-electron tomography, Bauerlein et al. reveal the fibrillary structure of huntingtin aggregates in situ and show that huntingtin fibrils interact with the endoplasmic reticulum, distorting its morphology and dynamics.
Medical subject headings
- Huntingtin Protein
- Nerve Tissue Proteins