Identification of a protective proteomic signature and a potential therapeutic target in diabetic nephropathy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28938946.
- Also identified by DOI 10.1016/j.kint.2017.08.002.
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Abstract
In a recent paper in Nature Medicine, Qi et al. set out to identify protective pathways in patients with longstanding diabetes who do not develop diabetic nephropathy. Unbiased proteomic analysis of kidney tissue identified a unique protein signature in unaffected individuals. Studies in vitro and in murine models identified the highly upregulated glycolytic enzyme pyruvate kinase M2 as a potential therapeutic target to prevent or treat diabetic nephropathy.
Medical subject headings
- Diabetic Nephropathies