Foreseeing the future of glomerular disease through slits: miR-NPNT axis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28938947.
- Also identified by DOI 10.1016/j.kint.2017.04.036.
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Abstract
Podocyte biology is an important key factor for the maintenance of glomerular function and structure. Nephronectin is a podocyte-derived extracellular matrix protein in the glomerular basement membrane. Suppression of nephronectin expression by microRNA-378a-3p significantly induced proteinuria due to loss of integrity of the glomerular filtration barrier in zebrafish and mice, demonstrating the relevance of the microRNA-nephronectin axis in regulation of the podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier.
Medical subject headings
- MicroRNAs
- Podocytes