Heart dose associated with overall survival in locally advanced NSCLC patients treated with hypofractionated chemoradiotherapy.
prospective_cohort · Level II
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- Record sourced from PubMed, PMID 28939179.
- Also identified by DOI 10.1016/j.radonc.2017.09.004.
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Abstract
Association of heart dose and overall survival was investigated in a cohort including 469 locally-advanced NSCLC patients receiving daily low-dose hypofractionated chemo-radiotherapy. Significant associations were found over a range of dose parameters. Multivariate analysis showed significant associations of heart_V<sub>2Gy</sub>:HR=1.007%<sup>-1</sup> (95% CI:1.002-1.013; p=0.006), age:HR=1.026year<sup>-1</sup> (1.011-1.042; p=0.001) and GTV volume:HR=1.001cc<sup>-1</sup> (1.000-1.002; p=0.006) with overall survival.
Medical subject headings
- Carcinoma, Non-Small-Cell Lung
- Chemoradiotherapy
- Heart
- Lung Neoplasms
- Radiation Dose Hypofractionation