MECAT: fast mapping, error correction, and de novo assembly for single-molecule sequencing reads.
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- Record sourced from PubMed, PMID 28945707.
- Also identified by DOI 10.1038/nmeth.4432.
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Abstract
We present a tool that combines fast mapping, error correction, and de novo assembly (MECAT; accessible at https://github.com/xiaochuanle/MECAT) for processing single-molecule sequencing (SMS) reads. MECAT's computing efficiency is superior to that of current tools, while the results MECAT produces are comparable or improved. MECAT enables reference mapping or de novo assembly of large genomes using SMS reads on a single computer.
Medical subject headings
- High-Throughput Nucleotide Sequencing
- Sequence Analysis, DNA