Computational prediction of therapeutic peptides based on graph index.

Abstract

As therapeutic peptides have been taken into consideration in disease therapy in recent years, many biologists spent time and labor to verify various functional peptides from a large number of peptide sequences. In order to reduce the workload and increase the efficiency of identification of functional proteins, we propose a sequence-based model, q-FP (functional peptide prediction based on the q-Wiener Index), capable of recognizing potentially functional proteins. We extract three types of features by mixing graphic representation and statistical indices based on the q-Wiener index and physicochemical properties of amino acids. Our support-vector-machine-based model achieves an accuracy of 96.71%, 93.34%, 98.40%, and 91.40% for anticancer, virulent, and allergenic proteins datasets, respectively, by using 5-fold cross validation.