EMHP: an accurate automated hole masking algorithm for single-particle cryo-EM image processing.
basic_science · Level V
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- Record sourced from PubMed, PMID 28961740.
- Also identified by DOI 10.1093/bioinformatics/btx500 and PMC identifier 5860320.
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Abstract
The Electron Microscopy Hole Punch (EMHP) is a streamlined suite of tools for quick assessment, sorting and hole masking of electron micrographs. With recent advances in single-particle electron cryo-microscopy (cryo-EM) data processing allowing for the rapid determination of protein structures using a smaller computational footprint, we saw the need for a fast and simple tool for data pre-processing that could run independent of existing high-performance computing (HPC) infrastructures. EMHP provides a data preprocessing platform in a small package that requires minimal python dependencies to function. https://www.bitbucket.org/chazbot/emhp Apache 2.0 License. bowman@scripps.edu. Supplementary data are available at Bioinformatics online.
Medical subject headings
- Algorithms
- Cryoelectron Microscopy
- Image Processing, Computer-Assisted