Detection of Host Response to Viral Respiratory Infection by Measurement of Messenger RNA for MxA, TRIM21, and Viperin in Nasal Swabs.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 28968760.
- Also identified by DOI 10.1093/infdis/jix458 and PMC identifier 7107421.
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Abstract
Respiratory viruses frequently cause symptomatic infections in children but are often detected also in healthy children. We investigated myxovirus resistance protein A (MxA), viperin, and tripartite-motif 21 (TRIM21) messenger RNA indexes in nasal swabs as potential biomarkers of viral respiratory infection in children. Respiratory viruses were detected by polymerase chain reaction in the same swabs. Nasal MxA and viperin indexes were increased in symptomatic virus-positive children. Nasal viperin index was found to be a robust marker of viral respiratory tract infection with a sensitivity of 80% and specificity of 94% in distinguishing children with symptomatic virus infections from asymptomatic virus-negative children.
Medical subject headings
- Host-Pathogen Interactions
- Myxovirus Resistance Proteins
- Proteins
- RNA, Messenger
- Respiratory Tract Infections
- Ribonucleoproteins
- Virus Diseases