Dietary Carbohydrates Impair Healthspan and Promote Mortality.

Ravichandran, Meenakshi; Grandl, Gerald; Ristow, Michael · Cell Metab · 2017

prospective_cohort · Level II

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Abstract

The prospective cohort study, named PURE, found that in >135,000 participants from 18 countries, nutritive carbohydrates increase human mortality, whereas dietary fat reduces it, requesting a fundamental change of current nutritional guidelines. Experimental evidence from animal models provides synergizing mechanistic concepts as well as pharmacological options to mimic low-carb or ketogenic diets.

Medical subject headings