The Burgeoning World of Immunometabolites: T<sub>h</sub>17 Cells Take Center Stage.
Level V
Where this comes from
- Record sourced from PubMed, PMID 28978422.
- Also identified by DOI 10.1016/j.cmet.2017.09.014.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Dysregulation of the Th17/Treg balance is a key driver of autoimmunity. A new study by Xu et al. (2017) has revealed that small-molecule inhibition of 2-hydroxyglutarate synthesis skews Th17 differentiation to the Treg lineage, which is protective against autoimmune inflammation.
Medical subject headings
- Aminooxyacetic Acid
- Autoimmunity
- Glutarates
- Small Molecule Libraries
- Th17 Cells