TREM2: Keeping Microglia Fit during Good Times and Bad.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 28978423.
- Also identified by DOI 10.1016/j.cmet.2017.09.010.
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Abstract
Microglia are the macrophages of the brain and play an important role in Alzheimer's disease (AD). In Cell, Ulland et al. (2017) recently reported that mutations in TREM2, a protein implicated in AD, disrupt microglial energy state and function, thus sabotaging the microglia's ability to defend the brain against amyloid plaques.
Medical subject headings
- Alzheimer Disease
- Membrane Glycoproteins
- Microglia
- Receptors, Immunologic