Guardians of the ERAD Galaxy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28985557.
- Also identified by DOI 10.1016/j.cell.2017.09.023.
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Abstract
The endoplasmic reticulum-associated degradation (ERAD) pathway facilitates the disposal of terminally misfolded proteins in the early secretory pathway yet spares folding intermediates from being destroyed. Zhang et al. report on a protein complex that acts as a guardian to protect these folding intermediates from being targeted for ERAD.
Medical subject headings
- Endoplasmic Reticulum-Associated Degradation
- Protein Folding