Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28988769.
- Also identified by DOI 10.1016/j.cell.2017.09.007 and PMC identifier 5687509.
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Abstract
We report a comprehensive analysis of 412 muscle-invasive bladder cancers characterized by multiple TCGA analytical platforms. Fifty-eight genes were significantly mutated, and the overall mutational load was associated with APOBEC-signature mutagenesis. Clustering by mutation signature identified a high-mutation subset with 75% 5-year survival. mRNA expression clustering refined prior clustering analyses and identified a poor-survival "neuronal" subtype in which the majority of tumors lacked small cell or neuroendocrine histology. Clustering by mRNA, long non-coding RNA (lncRNA), and miRNA expression converged to identify subsets with differential epithelial-mesenchymal transition status, carcinoma in situ scores, histologic features, and survival. Our analyses identified 5 expression subtypes that may stratify response to different treatments.
Medical subject headings
- Urinary Bladder Neoplasms