Jumping the Barrier: Modeling Drug Penetration across the Blood-Brain Barrier.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 29018050.
- Also identified by DOI 10.1158/1078-0432.CCR-17-2741 and PMC identifier 5732885.
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Abstract
Determining the penetration of drugs across the blood-brain barrier is a significant challenge in central nervous system drug development. The use of a mechanistic physiologically based pharmacokinetic model can predict drug exposures in the brain without needing <i>in situ</i> drug measurements. <i>Clin Cancer Res; 23(24); 7437-9. ©2017 AACR</i><i>See related article by Li et al., p. 7454</i>.
Medical subject headings
- Glioblastoma