DNA sequencing at 40: past, present and future.
review · Level V
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- Record sourced from PubMed, PMID 29019985.
- Also identified by DOI 10.1038/nature24286.
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Abstract
This review commemorates the 40th anniversary of DNA sequencing, a period in which we have already witnessed multiple technological revolutions and a growth in scale from a few kilobases to the first human genome, and now to millions of human and a myriad of other genomes. DNA sequencing has been extensively and creatively repurposed, including as a 'counter' for a vast range of molecular phenomena. We predict that in the long view of history, the impact of DNA sequencing will be on a par with that of the microscope.