SAGE2: parallel human genome assembly.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29045591.
- Also identified by DOI 10.1093/bioinformatics/btx648.
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Abstract
De novo genome assembly of next-generation sequencing data is a fundamental problem in bioinformatics. There are many programs that assemble small genomes, but very few can assemble whole human genomes. We present a new algorithm for parallel overlap graph construction, which is capable of assembling human genomes and improves upon the current state-of-the-art in genome assembly. SAGE2 is written in C ++ and OpenMP and is freely available (under the GPL 3.0 license) at github.com/lucian-ilie/SAGE2. ilie@uwo.ca. Supplementary data are available at Bioinformatics online.
Medical subject headings
- Genome, Human
- High-Throughput Nucleotide Sequencing
- Sequence Analysis, DNA
- Software