Ectopic colonization of oral bacteria in the intestine drives T<sub>H</sub>1 cell induction and inflammation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29051379.
- Also identified by DOI 10.1126/science.aan4526 and PMC identifier 5682622.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Intestinal colonization by bacteria of oral origin has been correlated with several negative health outcomes, including inflammatory bowel disease. However, a causal role of oral bacteria ectopically colonizing the intestine remains unclear. Using gnotobiotic techniques, we show that strains of <i>Klebsiella</i> spp. isolated from the salivary microbiota are strong inducers of T helper 1 (T<sub>H</sub>1) cells when they colonize in the gut. These <i>Klebsiella</i> strains are resistant to multiple antibiotics, tend to colonize when the intestinal microbiota is dysbiotic, and elicit a severe gut inflammation in the context of a genetically susceptible host. Our findings suggest that the oral cavity may serve as a reservoir for potential intestinal pathobionts that can exacerbate intestinal disease.
Medical subject headings
- Inflammatory Bowel Diseases
- Intestines
- Klebsiella
- Microbiota
- Mouth
- Th1 Cells