FUS Zigzags Its Way to Cross Beta.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29053965.
- Also identified by DOI 10.1016/j.cell.2017.10.007.
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Abstract
The low-complexity domain (LCD) of the FUS protein forms concentration-dependent assemblies, including liquid droplets and fibril-based hydrogels. The molecular structures of FUS within different assemblies and their functional relevance are subjects of intense debate. Murray et al. report an atomic-level structural model for FUS LCD fibrils that answers some questions and raises new ones.
Medical subject headings
- RNA-Binding Protein FUS