The function of the parathyroid oxyphil cells in uremia: still a mystery?
Level V
Where this comes from
- Record sourced from PubMed, PMID 29055426.
- Also identified by DOI 10.1016/j.kint.2017.06.024.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Parathyroid glands of young adults consist primarily of chief cells. However, with age or after excessive functional stress, another cell type increases progressively-the oxyphil cell. There is evidence for a chief-to-oxyphil cell transdifferentiation in chronic kidney disease. The latter may represent a defense mechanism, transforming the actively secreting chief cells to a less actively secreting cell type. However, even if this strategy is able to delay the development of secondary hyperparathyroidism, it cannot prevent it.
Medical subject headings
- Oxyphil Cells
- Parathyroid Glands