Disagreement of diameter and volume measurements for pulmonary nodule size estimation in CT lung cancer screening.
rct · Level II
Where this comes from
- Record sourced from PubMed, PMID 29056601.
- Also identified by DOI 10.1136/thoraxjnl-2017-210770.
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Abstract
We studied 2240 indeterminate solid nodules (volume 50-500mm<sup>3</sup>) to determine the correlation of diameter and semi-automated volume measurements for pulmonary nodule size estimation. Intra-nodular diameter variation, defined as maximum minus minimum diameter through the nodule's center, varied by 2.8 mm (median, IQR:2.2-3.7 mm), so above the 1.5 mm cutoff for nodule growth used in Lung CT Screening Reporting and Data System (Lung-RADS). Using mean or maximum axial diameter to assess nodule volume led to a substantial mean overestimation of nodule volume of 47.2% and 85.1%, respectively, compared to semi-automated volume. Thus, size of indeterminate nodules is poorly represented by diameter. Pre-results, ISRCTN63545820.
Medical subject headings
- Lung Neoplasms
- Mass Screening
- Multiple Pulmonary Nodules
- Solitary Pulmonary Nodule
- Tomography, X-Ray Computed