High-performance wireless powering for peripheral nerve neuromodulation systems.
basic_science · Level V
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- Record sourced from PubMed, PMID 29065141.
- Also identified by DOI 10.1371/journal.pone.0186698 and PMC identifier 5655495.
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Abstract
Neuromodulation of peripheral nerves with bioelectronic devices is a promising approach for treating a wide range of disorders. Wireless powering could enable long-term operation of these devices, but achieving high performance for miniaturized and deeply placed devices remains a technological challenge. We report the miniaturized integration of a wireless powering system in soft neuromodulation device (15 mm length, 2.7 mm diameter) and demonstrate high performance (about 10%) during in vivo wireless stimulation of the vagus nerve in a porcine animal model. The increased performance is enabled by the generation of a focused and circularly polarized field that enhances efficiency and provides immunity to polarization misalignment. These performance characteristics establish the clinical potential of wireless powering for emerging therapies based on neuromodulation.
Medical subject headings
- Peripheral Nerves
- Wireless Technology