Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29074844.
- Also identified by DOI 10.1038/s41467-017-01192-1 and PMC identifier 5658350.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Early-life stress, including maternal separation (MS), increases the vulnerability to develop mood disorders later in life, but the underlying mechanisms remain elusive. We report that MS promotes depressive-like symptoms in mice at a mature stage of life. Along with this behavioral phenotype, MS drives reduction of GABA<sub>B</sub>-GIRK signaling and the subsequent lateral habenula (LHb) hyperexcitability-an anatomical substrate devoted to aversive encoding. Attenuating LHb hyperactivity using chemogenetic tools and deep-brain stimulation ameliorates MS depressive-like symptoms. This provides insights on mechanisms and strategies to alleviate stress-dependent affective behaviors.
Medical subject headings
- Depression
- Habenula
- Maternal Deprivation
- Stress, Psychological