Molecular Profiling of Mammary Analog Secretory Carcinoma Revealed a Subset of Tumors Harboring a Novel ETV6-RET Translocation: Report of 10 Cases.
case_series · Level IV
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- Record sourced from PubMed, PMID 29076873.
- Also identified by DOI 10.1097/PAS.0000000000000972.
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Abstract
ETV6 gene abnormalities are well described in tumor pathology. Many fusion partners of ETV6 have been reported in a variety of epithelial, mesenchymal, and hematological malignancies. In salivary gland tumor pathology, however, the ETV6-NTRK3 translocation is specific for (mammary analog) secretory carcinoma, and has not been documented in any other salivary tumor type. The present study comprised a clinical, histologic, and molecular analysis of 10 cases of secretory carcinoma, with typical morphology and immunoprofile harboring a novel ETV6-RET translocation.
Medical subject headings
- Biomarkers, Tumor
- Gene Expression Profiling
- Gene Fusion
- Mammary Analogue Secretory Carcinoma
- Proto-Oncogene Proteins c-ets
- Proto-Oncogene Proteins c-ret
- Repressor Proteins
- Salivary Gland Neoplasms
- Translocation, Genetic