PAF1 complex component Leo1 helps recruit <i>Drosophila</i> Myc to promoters.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29078288.
- Also identified by DOI 10.1073/pnas.1705816114 and PMC identifier 5676885.
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Abstract
The Myc oncogene is a transcription factor with a powerful grip on cellular growth and proliferation. The physical interaction of Myc with the E-box DNA motif has been extensively characterized, but it is less clear whether this sequence-specific interaction is sufficient for Myc's binding to its transcriptional targets. Here we identify the PAF1 complex, and specifically its component Leo1, as a factor that helps recruit Myc to target genes. Since the PAF1 complex is typically associated with active genes, this interaction with Leo1 contributes to Myc targeting to open promoters.
Medical subject headings
- Drosophila
- Drosophila Proteins
- Promoter Regions, Genetic
- Proto-Oncogene Proteins c-myc
- Transcription Factors